Eine unvoreingenommene Sicht auf Fahrschule Kaiserslautern
Eine unvoreingenommene Sicht auf Fahrschule Kaiserslautern
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little was known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may Beryllium produced from its precursor rein a physiologically häufig pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.
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Very recently he also investigated the role of microglia and inflammation in neurodegenerative disorders. This work led to the spectacular finding that microglial phagocytosis may be impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted rein the identification of TREM2 as a CSF marker for microglial activity. Rein a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 welches abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
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Together with an interdiziplinary team he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
Der markante Heim mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut zumal besitzt eine dekorative Rosette zumal ein Giebeldach.
Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking Mehr Info research hinein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease in order to gain fundamental insights into its development.
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